effects of clarithromycin-containing quadruple therapy on helicobacter pylori eradication after nitroimidazole- containing quadruple therapy failure

نویسندگان

hafez fakheri

zeinab bakhshi

zohreh bari m.d, fellowship of gastroenterology, mazandaran university of medical sciences

saman alhoori

چکیده

background: several large clinical trials and meta-analyses have shown about 20% failure to eradicate helicobacter pylori ( h. pylori ), necessitating investigations for second-line treatments. the aim of this study was to evaluate the effects of clarithromycin-containing quadruple regimen after nitroimidazole-containing quadruple therapy failure. methods: thirty two patients who had failed 10-day h. pylori treatment with omeprazole, amoxicillin, bismuth subcitrate, and metronidazole (oabm)  regimen and 31 patients who had failed 10-day treatment with omeprazole, amoxicillin, bismuth subcitrate, and furazolidone (oamf) regimen entered the study. they all received omeprazole (20 mg), amoxicillin (1 gr), bismuth subcitrate (240 mg) and clarithromycin (500 mg) twice a day for 10 days. eight weeks after treatment, h. pylori eradication was assessed by ¹⁴c-urea breath test. results: totally 61 patients completed the study. according to intention to treat (itt) analysis, eradication rates by second-line oabc regimen were 84.37% (95% ci= 71.7–96.9%) in oabm group and 77.41% (95% ci= 62.71–92.11%) in oabf group (p=0.756). per-protocol (pp) eradication rates were 87.09% (95% ci= 75.2–98.8%) and 82.75% (95% ci= 79.4–96%), respectively (p=0.638). also the cumulative eradication rates by oabc regimen were 80.9% (95% ci= 71.2–90.6%) and 85% (95% ci= 75.9–94%) according to itt and pp analyses, respectively. severe side effects were reported in 3.1% of the patients. conclusion: regarding ideal eradication rate (>80%) and very low adverse effects, it seems that clarithromycin-containing quadruple therapy can be an encouraging regimen after nitroimidazole-containing regimen failure.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Clarithromycin-Containing Quadruple Therapy on Helicobacter Pylori Eradication after Nitroimidazole-Containing Quadruple Therapy Failure.

BACKGROUND Several large clinical trials and meta-analyses have shown about 20% failure to eradicate Helicobacter pylori (H.pylori), necessitating investigations for second-line treatments. The aim of this study was to evaluate the effects of clarithromycin-containing quadruple regimen after nitroimidazole-containing quadruple therapy failure. METHODS Thirty two patients who had failed 10-day H...

متن کامل

Berberine containing quadruple therapy for initial Helicobacter pylori eradication

BACKGROUND Due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for Helicobacter pylori (H pylori) eradication. However, different results are varied greatly and the availability of bismuth was limited in some countries. We assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an al...

متن کامل

Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes

AIM To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure. METHODS This study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori era...

متن کامل

Helicobacter pylori eradication in renal recipient: triple or quadruple therapy?

Although triple (omeprazole, amoxicillin, and metronidazole) and quadruple (omeprazole, tetracycline, metronidazole, and bismuth subcitrate) therapeutic regimens for H. pylori eradication has been studied much in the general population, there is a lack of data in renal transplanted patients. So, this study aimed at comparing regimens in these patients who were considered being immunocompromised...

متن کامل

Comparison of quadruple and triple Furazolidone containing regimens on eradication of helicobacter pylori

BACKGROUND The effectiveness of classic standard triple therapy regimen of helicobacter pylori (H. pylori) eradication has decreased to unacceptably low levels, largely related to development of resistance to metronidazole and clarithromycin. Thus successful eradication of H. pylori infections remains challenging. Therefore alternative treatments with superior effectiveness and safety should be...

متن کامل

helicobacter pylori eradication in renal recipient: triple or quadruple therapy?

although triple (omeprazole, amoxicillin, and metronidazole) and quadruple (omeprazole, tetracycline, metronidazole, and bismuth subcitrate) therapeutic regimens for h. pylori eradication has been studied much in the general population, there is a lack of data in renal transplanted patients. so, this study aimed at comparing regimens in these patients who were considered being immunocompromised...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
middle east journal of digestive diseases

جلد ۸، شماره ۱، صفحات ۵۱-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023